breast cancer is the second most commonly diagnosed cancer in women. ) about one in eight women in the united states will develop invasive breast cancer in her lifetime. Researchers estimate that more than 276,000 new cases of invasive breast cancer will be diagnosed in u. Male breast cancer represents less than 1 percent of all breast cancer. gene responsible for breast cancer identified researchers have identified a critical gene that could help clinicians distinguish fibroadenomas cases from breast cancer. A mutation in the cdh1 gene can increase the risk of forming lobular breast cancer, or cancer that begins in the breasts milk-producing lobules. Since the gene normally helps cells stick together, a mutation can also make it easier for individual cancer cells to break off from a breast tumor and metastasize , or spread to other parts of the body. Brca1 and brca2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged dna and, therefore, play a role in ensuring the stability of each cell s genetic material. Brca1 and brca2 are two different genes that have been found to impact a persons chances of developing breast cancer. Despite what their names might suggest, brca genes do not cause breast cancer. In fact, these genes normally play a big role in preventing breast cancer. To better understand breast cancer, it helps to understand how any cancer can develop. Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for regulating the growth of cells and keeping them healthy. The tumor susceptibility genes, brca1 and brca2, are found in about 80 of familial breast cancer cases and only 510 of all breast cancer cases (rosen et al.). Brca1 and brca2 the most common cause of hereditary breast cancer is an inherited mutation in the brca1 or brca2 gene. In normal cells, these genes help make proteins that repair damaged dna. Mutated versions of these genes can lead to abnormal cell growth, which can lead to cancer.
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